For example, a pet who is taking cimetidine and theophylline may become hyper-excitable, have a rapid heart rate, or even develop seizures.Ĭimetidine is not the only drug that inhibits CYP. Therefore, if you give a pet cimetidine and one of these other drugs (theophylline, aminophylline, lidocaine, and diazepam, to name a few), it is more likely that a pet will develop side effects similar to those seen with overdoses of the drug in question. Many different medications use CYP as part of the process of being cleared from the body. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). CimetidineĬimetidine (Tagamet) is an antacid that can be used to treat or prevent ulcers within a pet’s gastrointestinal tract. If it is necessary for a pet who is on one of these types of medications to start taking the other, veterinarians will typically recommend a “wash-out” period of around five days or so to prevent interactions between the drugs within the pet’s body. Affected pets may have a poor appetite, vomiting, or diarrhea, and can develop ulcers that bleed or even create holes within the GI tract.Īs a general rule of thumb, pets should never take NSAIDs and corticosteroids at the same time. Unfortunately, when they are given at the same time, or even within a few days of one another, gastrointestinal problems are likely.
Nonsteroidal anti-inflammatory medications (Rimadyl, Metacam, Deramaxx, Etogesic, etc.) and corticosteroids (prednisone, triamcinolone, dexamethasone, etc.) are two of the most frequently prescribed classes of medications in veterinary medicine. Let’s look at some of the drugs that can be involved in adverse interactions and what can be done to protect our pets.
An increased chance of unwanted side effects.
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